Endocrine Abstracts

Introduction: Pituitary adenomas (PA) represent approximately 15% of all intracranial neoplasms, with a global incidence of 15,20 per million per year. The immunohistochemical analysis of PA is necessary for diagnosis and plays an important role in the modern classification system of pituitary tumors.Material and methods: Samples from 142 surgically resected PA were studied immunohistochemically using antisera for 6 anterior pituitary hormones. Reticulin...

Background: Recurrenthyperparathyroidism following total parathyroidectomy with autotransplantation in patients with end-stage renal disease who are on hemodialysis is not an uncommon condition and can be due to hyperplastic autografted tissue, remnant parathyroid tissues in the neck or in the presence of ectopic and/or supernumerary parathyroid glands.Case report: We report the case of a 66-year-old patient with a history of chronic kidney disease on he...

Background: Overt newly diagnosed hyperthyroidism is frequently associated with mild anemia. However, there are limited data on long term evolution under methimazole treatment. Our aim was to study the baseline characteristics and evolution of anemia in the hyperthyroidism setting.Methods: We retrospectively assessed 58 consecutive patients [46 (79.3%) women] presenting with newly diagnosed overt thyrotoxicosis (43 Graves disease, 9 toxic nodular goiters...

Introduction: Gastrinomas are rare neuroendocrine tumours (NETs) that arise from enterochromaffin-like cells and produce gastrin. Most are discovered in the duodenum and pancreas. The clear cell type of renal cell carcinoma (RCC) is known for the expression of gastrin-releasing peptide receptor (GRP-R) and some studies have shown GRP can stimulate tumor cell proliferation and neoangiogenesis. Therefore, we present a case with metachronous development of renal cell carcinoma an...

Background: Growth hormone directly stimulates tumour growth, angiogenesis and metastasis through autocrine and paracrine effects on cancer cells, while through IGF1 inhibits apoptosis and promotes epithelial proliferation. Although disputed, some studies have shown an increased cancer incidence in acromegaly patients, especially in uncontrolled subjects, while others have not.Aim: To assess prevalence of cancer in a cohort of patients with long term tre...

Background: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. Standard treatment includes thyroidectomy (extention depending on tumour size, pathology and lymph nodes involvement). If indicated, radioiodine therapy after TSH stimulation either by levothyroxine withdrawal or rhTSH administration is recommended. In patients with thyrotropin deficiency rhTSH administration is mandatory.Case report: A 30-year-old woman, resident in...

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that is caused by mutations of genes involved with adrenal steroidogenesis. The mutations mostly occur in the 21-hydroxylase gene and rarely in the 3β-hydroxysteroid dehydrogenase gene or 11β-hydroxylase genes. Our aim is to present a series of 3 cases of patients with late onset CAH, probably due to 21-hydroxylase deficiency, after 50 years of age.Case series...

Background: The importance of carcinoembryonic antigen (CEA) assessment in the evaluation of medullary thyroid carcinoma is well known. The role of CEA in the assessment of other neuroendocrine tumors (NET) is not clear. We aimed to evaluate a possible correlation between CEA measurements and the aggressivity of NETs.Methods: We evaluated 56 (36 women) NETs followed in a tertiary center (23 gastrointestinal, 12 pancreatic, 10 pulmonary, 7 without primary...

Introduction: Endogenous Cushing syndrome (CS), is associated with significant morbidity (metabolic, cardiovascular, bone, psychiatric complications among others). Most complications tend to improve if hypercortisolism is controlled but some are only partially reversible or even experience temporary exacerbation.Patients and Methods: We report 2 cases of adrenal Cushing Syndrome (CS). The first is a 72 years-old female with CS caused by bilateral macrono...

Introduction: Hyponatremia, defined as a serum sodium concentration below 135 mEq/l, has a heterogeneous etiology, the main endocrine causes includind the syndrome of inappropiate antidiuresis (SIAD), adrenal insufficiency and severe hypothyroidism.Materials and methods: Clinical, hormonal and imaging evaluationAim: To present a case of hyponatremia leading to the diagnosis of a large pituitary tumorCase pres...